The REMI PI+ model was applied in this analysis of the potential regional macroeconomic impacts of a set of ten greenhouse gas mitigation policy options intended to enable the Southern California Association of Governments to comply with the state’s greenhouse gas reduction targets. The PI+ model was important to this study because it divided the economy into 169 individual sectors so as to allow for important differentials to be analyzed and incorporate labor and capital market features, as well as trade with other states or countries. The macroeconomic analysis results indicated that, as a group, the recommended greenhouse gas mitigation policy options yield a net positive impact on the Southern California Association of Governments Region’s economy in terms of employment but a slightly negative impact on gross domestic product.